Predicting NFL Week 12 upsets and fantasy football sleepers, plus buzz and notes around the league

It's Week 12 of the 2021 NFL season, and we asked our insiders Dan Graziano and Jeremy Fowler for insight on the biggest news and for their picks on games and players to watch this weekend.

After naming their NFC top picks last week, they tackle the favorites in the AFC, choosing their top teams in the conference. Are the current No. 1-seeded Tennessee Titans still the best of the AFC? They also look at players who could break out as the calendar churns toward December. Who are the names to watch for huge stretch runs?

But first, they give their thoughts on possible upsets this week. Will the Indianapolis Colts keep it rolling against the defending Super Bowl champion Tampa Bay Buccaneers? And for fantasy managers looking to make all the right moves, our insiders name must-start sleepers. They get into all of it, emptying their notebooks with everything they've heard this week, including the health of the Green Bay Packers' defense and the Titans' wide receivers.

Let's get started with the upset picks of the week, but you can also jump to other big questions for Week 12.

Jump to:
Stretch-run breakout stars
AFC No. 1 seed | Underrated gems
Notebook: Everything we're hearing

What's your top upset pick for Week 12?