Coach Romeo Crennel said Monday that Faine, who started the first 14 games, might need surgery. The Browns are expected to place Faine, 24, on injured reserve, where he has finished each of his three seasons.
Still, Crennel isn't concerned with Faine's history of injuries, and the coach said he's pleased with the center's performance.
"Jeff has done a nice job," Crennel said. "Coming in, there was some questions about his size and toughness and how well he would hold up. But I think he did well."
A first-round pick in 2003 from Notre Dame, Faine has started 36 games in his pro career. Before being hurt, he was Cleveland's only first-round pick still starting since the club rejoined the NFL in 1999.
Faine was injured in the first half of Sunday's 9-7 victory over the Raiders.
Crennel praised backup Mike Pucillo for his job in replacing Faine. Pucillo is expected to start Cleveland's final two home games, against Pittsburgh and Baltimore.
"He went in and blocked who he was supposed to block and didn't get knocked around too much," Crennel said.