Mawae has not practiced since hurting his right elbow Dec. 21.
The team issued its final injury report Friday and listed Mawae as out. That means second-year lineman Leroy Harris will start his second straight game and his first playoff game.
Reserve defensive end Dave Ball (back) also will be out for Saturday's game.
Cornerback Nick Harper (groin), defensive tackle Albert Haynesworth (knee), linebacker David Thornton (hip), defensive end Kyle Vanden Bosch (groin) and tight end Bo Scaife (illness) were listed as probable.