The Arizona Cardinals lost the one player that they could not afford to lose, while another injury drew the ire of coach Bruce Arians.
Arizona also lost star cornerback Patrick Peterson to an ankle injury, but it was defensive end Calais Campbell's knee injury that angered Arians, who referred to it as "the dirtiest play I've ever seen."
Campbell suffered an MCL injury when he was chop blocked by Broncos tight end Julius Thomas on Arizona's opening drive of the second half.
"I've been coaching for 37 years, and it's the dirtiest play I've ever seen in the National Football League," Arians said. "It was a flat chop block that put him out of the game. I've never seen anything like it. I know [Broncos coach] John Fox, and he's a great coach and a great guy. Somebody has got to answer to that.
"A fine isn't going to do it when [Campbell is] going to miss three to four weeks on a blatant chop block."
Thomas defended himself when told about Arians' comments by USA Today Sports and said that he sought out Antonio Cromartie to have the Cardinals cornerback deliver a message to Campbell.
"I guarantee that being dirty is not a part of my game, and to intentionally hurt somebody is not something I would ever do," Thomas told USA Today Sports.
Arians speculated that Campbell might have suffered a partial tear, but called it at minimum a sprain.
Stanton, who was wearing sunglasses as he exited the locker room, will go through the league's concussion protocol this week. He was hit by Broncos linebacker Von Miller on an incomplete pass on third-and-8 with 12:18 left in the third quarter.
With Arizona's starter, Carson Palmer, already inactive because of a nerve injury in his right shoulder, the Cardinals turned to third-string quarterback Logan Thomas, whose only completion on eight attempts went for an 81-yard touchdown to running back Andre Ellington.
Peterson, who left the game in the fourth quarter with a low left ankle sprain, thinks he avoided a major injury.
"I'll be OK," Peterson said. "Just got to get back to Arizona and maintain it and do a little bit of rehab, and I'll be ready for Sunday. It's just a mild bump in the road. I'll be OK."
Palmer will remain in Denver overnight to continue to receive treatment on the shoulder. The veteran quarterback threw about 20 passes earlier Sunday and felt as if he made some progress.