Bradley said Gerhart wanted to play through the injury, but the coaching and medical staff made the decision to hold him out against the Titans.
Gerhart suffered the injury in the season opener against Philadelphia but didn't miss time in the next three games. He re-injured the foot in last Sunday's loss to Pittsburgh.
"It's frustrating and disappointing," said Gerhart, who leads the Jaguars with 123 yards rushing. "It's something that's been dragging on since the horse collar at Philly. Trying to push through it and starting to feel good and then have a play and it takes a step back.
"I wish I was out there. I guess it's part of the game, but just sad about it."
Gerhart practiced fully Wednesday, but he suffered a setback and did not practice Thursday or Friday.
"I'm going to keep pushing and trying, but they said at this point you need to take a step back, and the best thing for it is time," Gerhart said. "I wish we were on a bye week right now instead of having to miss a game. I think in the long run, this will be best for me to get healthy and for the team moving forward."
The Jaguars, however, will have a full complement of receivers for the first time this season.
Cecil Shorts III (hamstring) and Marqise Lee (hamstring) practiced fully on Thursday and Friday. Lee has missed the last three games and Shorts did not play against Pittsburgh after injuring his hamstring against San Diego on Sept. 28.