Guion was found to have 357 grams of marijuana after his truck was pulled over Tuesday night.
The officer who searched the truck also found more than $190,000 in one of the bags in which the marijuana was located, according to the police report. Both the currency and truck were seized and secured due to the amount of marijuana found.
According to the police report, Guion was "extremely uncooperative and hostile" while the truck was initially searched. The officer reported that Guion "kept coming toward the vehicle several times saying, 'Hey man, my money is in there. Don't let him take my money.'"
Guion then was secured in handcuffs.
Police said the total amount of cash was $190,028.81.
Guion was initially pulled over by police for "failure to maintain a single lane," according to the report. The 315-pound Guion was partially hanging out of the driver's side window, at which point the officer smelled marijuana, the report said.
Guion told police he had a weapon that was registered to him, and they found a 9mm semi-automatic handgun.
A source with knowledge of the details told ESPN NFL Insider Adam Caplan the handgun was unloaded in a box and that Guion has a permit to carry it in Minnesota.
Guion was in the process of moving back from Green Bay to his home in Starke, the source said.
The source said further that Guion, after cashing his Packers paychecks, was going to use the money to help his family in Starke, and he provided proof of the money's origin through recent bank statements.
According to the Bradford County Sheriff's Office, Guion was released on $100,000 bond.
Guion, 27, joined the Packers last offseason and started every game. The former Minnesota Viking recorded a career-best 3.5 sacks.
He signed a one-year, $1 million contract and had been in negotiations with the Packers about a long-term deal.
"We are aware of a serious matter involving Letroy Guion," the Packers said in a statement. "We have not yet spoken to Letroy and we will have no further comment."
Guion's agent, Seth Katz, said Wednesday he was still gathering information about the arrest.