Coach Jack Del Rio said after the game that Murray is going through the league's concussion protocol.
Murray left the game late in the third quarter after being hit by Pittsburgh safety Mike Mitchell. Murray slumped to the ground and fumbled the ball, which was recovered by Pittsburgh. He did not return.
Del Rio did not give any further details on Murray's situation. Because Murray is going through the NFL's concussion protocol, he will have to pass a series of tests before he is allowed to practice and play.
The Raiders, who fell to 4-4, host Minnesota next week.
Also Sunday, Oakland center Rodney Hudson left in the fourth quarter with a lower-leg injury. Hudson, who signed a five-year, $44 million deal as a free agent from Kansas City this year, did not return. He was replaced by little-used Tony Bergstrom.
The Raiders had no information on Hudson's status after the game.