"[It's] pretty frustrating," Ryan said Friday. "If we knew the answer, we wouldn't have those problems. It's unbelievable because we let the clock run out on us a few times. We had to take a bunch of timeouts based on that. It's just hard -- we have no idea what it is. Sometimes it goes out; sometimes it doesn't. I think it's our responsibility as a team."
The Bills exhausted all of their second-half timeouts by early in the fourth quarter.
"It's kind of out of our control," quarterback Tyrod Taylor said Thursday. "We got to keep continuing to fight through it. We wasted some timeouts on it. It's unfortunate but moving forward, hopefully we won't have those problems."
The Bills were using wireless communication systems for Thursday night's game but used wired headsets in London last month, when the team also experienced coach-to-quarterback communication problems during their 34-31 loss to the Jacksonville Jaguars.
"We had a lot of issues with those," Ryan said Friday.
The Bills' coach-to-quarterback system experienced more issues than their coach-to-defense system, Ryan said.
"It comes up at certain times in the game, in critical situations, it seems like," Ryan said. "I have no answer for it."