Arizona placed Johnson on injured reserve with a designation to return on Tuesday, two days after he suffered a fractured tibia in his left leg in a 19-13 win on the road against the San Francisco 49ers.
Johnson, 30, will be eligible to play in eight weeks, just as the Cardinals would begin preparations for Super Bowl 50, if they were to qualify. He'll be eligible to return to practice in six weeks.
Johnson suffered the injury in the third quarter at Levi's Stadium.
He was fourth in the NFL in rushing with 814 yards and was on pace for his first 1,000-yard season since 2013.
Arizona promoted running back Kerwynn Williams from the practice squad. The Cardinals also signed cornerback Corey White and released cornerback Robert Nelson.