However, Titans interim coach Mike Mularkey said Monday that Mariota has not been ruled out for the season. Mularkey said the sprain will keep the rookie out of Sunday's home finale with Houston, but that Mariota will be re-evaluated after that game and wants to play the season finale at Indianapolis on Jan. 3.
Mularkey said Mariota's injury is less serious than the sprained left knee that kept the quarterback out of two games earlier this season.
Mariota, the No. 2 pick in the 2015 draft out of Oregon, was hurt when sacked for the third time at 10:32 of the second quarter in a 33-16 loss at New England.
Zach Mettenberger relieved Mariota and hit on 20 of 28 passes for 242 yards, two touchdowns and two interceptions.
Information from The Associated Press was used in this report.