Brees excelled against the porous Jacksonville pass defense, going 25-for-36 with 412 passing yards and three touchdowns and no turnovers as New Orleans improved to 6-9.
Brees, who returned to practice on a limited basis Friday, had insisted he would play and that the game plan wouldn't be limited based on the injury to his right heel.
"It hurts to walk. It has its challenges," Brees said earlier this week. "But we've come up with a good plan for this week, how to support it and how to make it as manageable as possible."
The Saints played without receiver Marques Colston, who suffered a chest injury Monday versus the Lions.
Tight end Benjamin Watson, who has been limited with a knee injury, was active for the Saints.
ESPN Staff Writer Mike Triplett contributed to this report.