Wilson found tight end Chase Coffman for an 8-yard score in the second quarter, setting a new franchise record for passing touchdowns in a single season. The previous mark was held by Dave Krieg, who tossed 32 touchdowns in 1984. Wilson threw three first-half touchdowns, giving him 34 on the season.
Wilson's 4,024 yards also set the franchise record for most passing yards in a season, surpassing Matt Hasselbeck's previous mark of 3,966 in 2007.
Overall, he completed 19-of-28 passes for 197 yards and three touchdowns as the Seahawks snapped Arizona's nine-game win streak in a 36-6 rout.
Wilson became the first player in NFL history with at least 4,000 yards passing, 30 touchdown passes and 500 yards rushing.