Quarless posted on Instagram that "my season has come to an end not by choice," despite being on the practice field for the Packers earlier Thursday.
According to a source, the move is injury related.
Quarless was added to the injury report earlier this week with a knee injury. He was listed as a limited participant on both Wednesday and Thursday.
The Packers did not announce a roster move, but it could come Friday before they depart for Saturday's NFC divisional playoff game at the Arizona Cardinals.
Quarless recently underwent a procedure to have fluid drained from his knee, the source said. A Week 3 knee injury landed Quarless on the injured reserve/designated to return list. He was eligible to come off the list for the Nov. 26 game against the Chicago Bears but was not activated until just before the Dec. 27 matchup at Arizona.
It's been a difficult year for Quarless. He was arrested in July for firing a gun in public and reached a plea agreement in November on the charge. He paid a $1,000 fine and was sentenced to one year of probation. He still could face discipline from the NFL.
Shortly after the July incident, his daughter died upon delivery.
Without Quarless, the Packers likely will be missing at least two players on offense for Saturday's game. Receiver Davante Adams is not expected to play after he suffered a sprained MCL in last weekend's playoff win over the Washington Redskins.
The Packers might decide they need Quarless' roster spot for either a tight end or receiver.