Hopkins, who is entering the fourth and final year of his rookie deal, did not report for the start of camp. He will be subject to fines of $40,000 for each day of camp he misses.
"We are disappointed DeAndre has elected not to report to training camp with the rest of his teammates," Texans general manager Rick Smith said in a statement Saturday. "He has expressed his position regarding his contract status, and we have been clear with both he and his representatives of ours.
"Our focus is on the 2016 season and all of our collective efforts and attention will be centered on that endeavor."
The Texans have subsequently placed Hopkins on the reserve/did not report list.
Hopkins was spotted at the team facility Friday night, sources told ESPN, but cleaned some belongings from his locker and left without reporting.
Because the Texans picked up the fifth-year option on Hopkins' contract in May, he technically has two seasons left on his deal. He also has a $445,000 roster bonus due Wednesday, the fifth day of camp, that he will miss out on if he hasn't returned by then.
A week ago, Hopkins expressed hope that his contract situation would resolve itself this offseason.
"I'm not looking for a certain range," Hopkins said during a break at a football camp for local children. "I just want to be treated for what I'm worth. That's fair to say, right?"
Hopkins was a rare bright spot for a troubled Texans offense last season. He became the first player in NFL history to record 100-yard games from four different quarterbacks in the same season. He finished the year with 111 catches, 1,521 yards and 11 touchdowns.