Here are the most significant NFL players who got banged up in Week 7:
LeSean McCoy, RB, Buffalo Bills: McCoy tried to play Sunday after injuring his hamstring during the week. But he was largely ineffective (11 yards on eight carries), and the team eventually ruled him doubtful to return to the game.
Geno Smith, QB, New York Jets: Smith can't catch a break. After waiting a year to get his starting job back, Smith got sacked, went down awkwardly and suffered a knee injury in the second quarter. Ryan Fitzpatrick, whom the team benched this week in favor of Smith, came into the game for the Jets. Smith showed up on the sideline in street clothes in the second half, after the team ruled him out for the game. Smith said after the game that he didn't think the injury was "anything too significant," but on Monday, coach Todd Bowles confirmed that Smith tore his ACL.
Josh Norman, CB, Washington Redskins: Norman stayed down on the field after landing hard on his head following a deep catch from Lions WR Marvin Jones. The cornerback walked off the field slowly, immediately went to the locker room for further concussion testing and was eventually ruled out for the game. He had shut Jones down all game prior to the 52-yard catch.
Tevin Coleman, RB, Atlanta Falcons: Coleman left Atlanta's game against San Diego with a hamstring injury in the second half. The team listed him as questionable to return, and TV cameras showed him limping to the locker room. Coleman, who recorded 74 total yards and a TD before being forced from the game, did not return.
Cody Kessler, QB, Cleveland Browns: Kessler took a shot as he bought extra time on a red zone play in the second quarter. The play resulted in an 11-yard gain, which eventually propelled the Browns to the end zone, but Kessler was taken to the locker room to be evaluated for a concussion. The team eventually ruled him out. Rookie Kevin Hogan, whom the Browns had been using as a zone-read QB against the Bengals when Kessler was healthy, took over as the starter. Hogan is the sixth quarterback to take a snap for the Browns this season.
Darius Slay, CB, Detroit Lions: Slay grabbed his right hamstring during the second quarter. He had to be helped off the field, and after being evaluated on the bench, he went back to the locker room. Johnson Bademosi replaced Slay in the lineup, and the Lions' star CB did not return.
Antonio Brown, WR, Pittsburgh Steelers: Brown left the game late in the third quarter following a short-yardage catch. After lying on the sideline in pain and trying to stretch out his thigh/hip, Brown limped to the locker room. He returned to the field after a very short absence but was clearly not 100 percent, as he favored his left leg. Brown will have the bye week to get right.
Arik Armstead, DT, San Francisco 49ers: Armstead has been battling a shoulder injury all season and appeared to reinjure it in the second half against Tampa Bay. Armstead was in pain, as he lay on the sideline holding the shoulder and getting more medical attention. He did not return to the game.
Trent Williams, LT, Washington Redskins: Williams injured his knee in the final seconds against the Lions. After the game, coach Jay Gruden said Williams had a sprained knee and would have an MRI on Monday. According to ESPN Redskins reporter John Keim, Williams was walking with a severe limp in the locker room.
Mike Evans, WR, Tampa Bay Buccaneers: Evans took a huge shot from 49ers CB Jimmie Ward as he was trying to make a tackle following a Jameis Winston interception at the end of the first quarter. He stayed down on the field for a while before walking off the field slowly with trainers. Evans came back into the game on the Bucs' next possession.
Jeremy Hill, RB, Cincinnati Bengals: Hill hadn't rushed for more than 71 yards in a game this season, but he had rushes of 74 and 40 yards against the Browns on Sunday. He left the game early in the fourth quarter because of a chest injury. With the game in hand, Hill did not get another carry, but the team's listing him as probable is a good sign for his status next week.
Nick Mangold, C, New York Jets: Mangold limped off the field and immediately went to the locker room in the first quarter after RT Ryan Clady rolled up on his ankle. The Pro Bowl center did not return to the field, and coach Todd Bowles said on Monday that Mangold has a sprained ankle.
Andrew Sendejo, S, Minnesota Vikings: Sendejo injured his ankle at the tail end of his interception return in the first quarter and was carted to the locker room. Rookie Jayron Kearse replaced Sendejo, and the safety did not return. Coach Mike Zimmer called Sendejo day-to-day on Monday.
Andrew Whitworth, T, Cincinnati Bengals: Whitworth (head injury) was ruled out of the Bengals' game against the Browns in the fourth quarter. According to ESPN Bengals reporter Katherine Terrell, coach Marvin Lewis said Whitworth was "fine," but the O-lineman was off-limits to the media after the game because he was in concussion protocol, which puts his status for next week in question.
Brandon Scherff, G, Washington Redskins: Coming off his best game this season, Scherff went down with a left shoulder injury in the first half against Detroit. Arie Kouandjio replaced Scherff before he eventually returned to the lineup. According to ESPN Redskins reporter John Keim, Scherff said his shoulder was sore after the game but he was OK.
Aaron Williams, S, Buffalo Bills: Dolphins WR Jarvis Landry launched himself into Williams, and the safety stayed on the ground for several minutes while trainers evaluated him. He suffered head and neck injuries and did not return to the field.
Ron Brooks, CB, Philadelphia Eagles: Brooks sustained what looked to be a serious knee injury in the first quarter against the Vikings. He stayed down on the field for a while as trainers stabilized his right leg. Brooks was carted to the locker room. Coach Doug Pederson announced on Monday that Brooks ruptured his quad and will miss the remainder of the season.
Terrance West, RB, Baltimore Ravens: West limped off the field after the Ravens' first play of the game. Rookie Kenneth Dixon replaced him in the lineup for the remainder of the series, but after his ankle was retaped, West returned to the game.