Anderson had an arthroscopic procedure to repair the meniscus in his right knee this week, according to the Broncos.
With Anderson on injured reserve, he has to be out for at least six weeks before he can return to practice and has to be out for a minimum of eight weeks before he can play in a game. The Broncos have only nine regular-season games remaining.
Anderson is still hoping to return for the playoffs.
Was an amazing fun year all I can do is rest up get back for the playoffs and if not get back and grind 4 next season— Cj Anderson (@cjandersonb22) October 28, 2016
Anderson suffered the injury during an 11-yard run on the final play of the first quarter in the Broncos' 27-9 victory over the Houston Texans on Monday night. As he closed in on Texans cornerback A.J. Bouye, Anderson tried to make a cut just before contact, planting his right foot, and his knee buckled slightly as he was tackled.
He sat on the field for several moments after the play, talking to the Broncos' trainers, and at one point he grabbed his lower right leg. Anderson returned to the game in the second quarter, with a 3-yard run eight plays later.
Anderson finished the game with 107 yards on 16 carries.
Rookie Devontae Booker, who had 83 yards rushing against the Texans on Monday night, will start Sunday's game against the San Diego Chargers. Kapri Bibbs will be the No. 2 running back, and the Broncos activated Juwan Thompson, who has been on the roster the previous two seasons, from the practice squad Saturday.
The Broncos matched an $18 million offer sheet to Anderson from the Miami Dolphins this offseason. Anderson has 437 yards rushing this season to go with four rushing touchdowns.
ESPN's Adam Schefter, Field Yates and Jeff Legwold contributed to this report.