When asked if Vereen re-tore the same triceps that cost him nine games this season, McAdoo responded:
"Yeah, Shane re-injured his triceps. It's unfortunate. He worked his tail off to get back to where he was, and I'm disappointed for Shane."
Vereen originally injured his triceps in a Week 3 victory over the Washington Redskins.
He returned to field on Dec. 11 in the Giants' 10-7 win over the Dallas Cowboys, only to be placed in concussion protocol during that game.
He had been a limited participant in practice leading up to game against Detroit.
ESPN's Jordan Raanan contributed to this report.