Abdul-Quddus suffered a neck injury Sunday in the overtime win against the Buffalo Bills.
Abdul-Quddus was quietly one of Miami's best free-agent pickups in the offseason. He started 15 games and finished with 78 tackles and two interceptions. The safety also played his best football and took on a leadership role in the secondary when former Pro Bowl safety Reshad Jones was lost for the season with a shoulder injury.
Miami (10-5) qualified for the playoffs and will play either the Pittsburgh Steelers or Houston Texans in the wild-card round. The Dolphins will host the New England Patriots in the regular-season finale on Sunday.