Overton Deshan Good, 23, was struck by a bullet and killed during an apparent drive-by shooting at a mobile home, according to the Cherokee County (South Carolina) sheriff's officials.
"The Indianapolis Colts family is so saddened to learn of the passing of Overton Good, brother of our very own Denzelle Good, in South Carolina," the team said in a statement. "This tragedy is unimaginable for his loved ones and friends, and our heartfelt prayers go out to Denzelle and his entire family during this trying time."
Denzelle Good did not participate in the Colts' walk-through practice Tuesday and was listed on the team's injury report as a nonparticipant due to a personal matter. The team plays Thursday at New England.
Good has started 21 games for the Colts since being selected in the seventh round of the 2015 draft. Rookie Braden Smith spent time working at right tackle during Indianapolis' walk-through Tuesday and is a possibility to start if Good is inactive against the Patriots.
The Cherokee County sheriff's department said 20-year-old Jermaine Jefferies has been arrested and charged with the murder of Overton Deshan Good.