"I mean, if it was anybody else, any other quarterback, he would have already been replaced," Owens told TMZ. "So, at this point, give someone else an opportunity.
"... He's accomplished a lot, but at the end of the day, the writing's on the wall."
The Giants' offense has struggled mightily during the team's 1-7 start. Not helping are struggles on the offensive line. Manning, 37, only has eight touchdown passes in eight games and has already been sacked 31 times; his career high for a season is 39.
"You have special players that are behind those not-so-great lines that can make something out of nothing," Owens told TMZ. "Eli's not one of those types of quarterbacks. He needs protection."
Beckham has been told by Giants co-owner John Mara that he should do "more playing and ... less talking." He has 61 receptions, which ranks second in the NFL, for 785 yards (fourth), but just two touchdowns this season.
"Odell can't perform because the quarterback is not performing," Owens said. "So, they should basically replace the quarterback. ... His skills are pretty much eroding and he's not really giving the guys an opportunity."
The Giants, who are on their bye week, visit the San Francisco 49ers on Nov. 12.