Jones injured the knee in the second half against Chicago on Sunday and has missed the entire week of practice leading up to Sunday's game against Carolina. He was ruled out for the game on Friday.
A source told ESPN Insider Adam Schefter on Tuesday that Jones suffered a bone bruise and would be "day-to-day" but that the ACL and MCL were intact.
With Jones out of the lineup, the Lions will lean more heavily on Kenny Golladay as the team's primary receiver against the Panthers. TJ Jones would likely replace Marvin Jones in the starting lineup, and Bruce Ellington, Brandon Powell or running back Theo Riddick would play in three-receiver sets.
Detroit also has an extra roster spot and two receivers, Andy Jones and Chris Lacy, on the practice squad.
Jones, who has 35 catches for 508 yards and five touchdowns this season, is one of Lions quarterback Matthew Stafford's top targets and most reliable deep-threat receivers.