Weddle suffered a head laceration and is under evaluation for a concussion, the team announced.
Weddle was attempting to tackle Panthers running back Christian McCaffrey before McCaffrey hurdled him, and Weddle took a knee to the head.
He finished with two tackles and thanked fans for their support on social media.
Thanks for all the thoughts and prayers. I'm good as gold. Now let's go finish this game with a DUB!!!!— Eric Weddle (@weddlesbeard) September 8, 2019
A 13-year pro, Weddle signed a two-year, $10.5 million deal with the Rams in free agency after he was released by the Baltimore Ravens.
Weddle, 34, has quickly established himself in the Rams' defense. He took over for linebacker Cory Littleton as the defensive signal-caller and was named a team captain.