Jackson produced the most rushing yards (120) ever for a player who threw for over 250 yards in the same game, according to ESPN Stats & Information.
Asked what opposing defenses can do when Jackson is both throwing and running effectively, Ravens coach John Harbaugh said, "It's just going to be a real conundrum for [opposing defenses]. It's going to be a real challenge for them to figure that out."
In his ninth NFL start, Jackson became the sixth player since the 1970 merger to record at least 250 passing yards and 100 rushing yards in a single game. He joins Cam Newton (who did it three times), Colin Kaepernick, Marcus Mariota, Russell Wilson and Michael Vick.
Jackson, though, was visibly upset throughout most of his postgame news conference.
"I like [my performance] was all right," Jackson said. "I could have been better. There were a lot of passes I want back; some sacks I want back. But we came out with the victory."
Jackson completed 24 of 37 passes (64.9 percent) for 272 yards and two touchdowns. His best throw came in the fourth quarter, when he converted a third-and-11 with a 41-yard strike to Marquise "Hollywood" Brown that sealed the win with 2 minutes, 57 seconds remaining.
"He couldn't have thrown it any better than that," Brown said. "He put it in a great spot, and all I had to do was hold my line."
Jackson's runs were the biggest difference from the season opener in Miami, where he carried the ball three times. On Sunday, Jackson ran for 120 yards on 16 carries.
"I just had to take what the defense gave me, and sometimes I had to run," Jackson said. "Sometimes I had to make scrambles because they had a great coverage, and some of our guys weren't open. I just had to move the sticks."
What does Jackson prefer: success throwing like he had last week or running like did Sunday?
"I'd rather throw," Jackson said. "That's what my job is; just get the ball to my guys. I'd rather throw than run."
Jackson continued to drive the point that he can be an effective passer in the NFL with another passing record.
Jackson threw his seventh touchdown pass in just his fifth quarter of work this year, surpassing his entire total (six) from last season. That also ranks as the most touchdown passes through the team's first two games in franchise history.
After throwing five touchdowns in three quarters last Sunday, Jackson connected on a 27-yard touchdown pass to tight end Mark Andrews and hit tight end Hayden Hurst for a 1-yard score in the first half this week.
Jackson threw his seventh touchdown pass on his 36th pass attempt of the season. Last season, Jackson recorded six touchdown passes on 170 attempts.
"It was good to see how much he has grown from last year," said linebacker Terrell Suggs, who is now with the Cardinals. "He's an NFL quarterback now, and he's phenomenal."
Jackson improved to 8-1 as a starting quarterback. Only 12 other quarterbacks in the Super Bowl era started their careers 8-1 or better through nine starts.