The team re-signed cornerback Tye Smith to take Butler's spot on the 53-man roster.
Butler broke his wrist while trying to break up a pass in the Titans' Week 9 loss to the Carolina Panthers. The sixth-year pro was having a solid second season in Tennessee, having recorded two interceptions and nine pass breakups.
LeShaun Sims will start at right cornerback in place of Butler.
Butler, a two-time Super Bowl champion, signed a five-year, $61 million contract with the Titans in March 2018.