The women told USA Today that Guice assaulted them in their own apartments following nights of heavy drinking.
The women said they shared their allegations with multiple people at LSU, including at least two coaches, an athletics administrator and a nurse. The women said the school failed to investigate and didn't interview them or potential witnesses.
The NFL team released Guice on Aug. 7, two hours after he was arrested on three separate domestic violence charges in Virginia.
"At no time were allegations of physical or sexual assault brought against Derrius during his years as a student athlete at LSU," Guice's attorney, Peter D. Greenspun, said in his statement given to USA Today. "To bring up such assertions only after the Virginia charges were initiated certainly calls into question the credibility, nature and timing of what is being alleged years later."
Neither woman reported the incidents to law enforcement, according to the report.
"LSU and LSU Athletics take all accusations of sexual assault with the utmost seriousness," the school said in a statement to ESPN. "Formal complaints are promptly and fully investigated and the rights and privacy of students are protected as stipulated by the Family Educational Rights and Privacy Act. Complainants are also strongly encouraged to report the offense to law enforcement and are provided information on health care, counseling and supportive measures available."
Guice, who was expected to be a first-round pick in the 2018 NFL draft, was selected by Washington in the second round (59th pick). He denied he was involved in a pre-draft altercation during a visit with the Philadelphia Eagles.
Guice tore his ACL in his left knee during the 2018 preseason and didn't make his pro debut until 2019. He had 42 rushes for 245 yards and two touchdowns last season.
At LSU, Guice rushed for 3,074 yards and 29 touchdowns in three seasons. He had three career 250-yard games, the most by any player in SEC history.
Guice, 23, is scheduled to be arraigned on the domestic violence charges on Aug. 28 in Loudoun County District Court.