It's uncertain when Doyle was injured, but he did not practice all week.
Doyle, a two-time Pro Bowl selection, had 43 receptions for 448 yards and four touchdowns last season. His absence leaves a significant void at tight end for the Colts (0-1), who are already without Trey Burton (calf).
"This is my first game without Jack or Eric [Ebron] with me," said Alie-Cox, who is in his third season. "I was just thinking, 'Dang, I'm the old guy of the group now.'"