San Francisco 49ers lose TE Jordan Reed, CB Emmanuel Moseley vs. New York Giants

Add two more key players to the San Francisco 49ers' ever-expanding list of injuries.

Tight end Jordan Reed (knee, ankle) and cornerback Emmanuel Moseley (concussion) suffered injuries in the first half of the team's game against the New York Giants on Sunday. Neither player returned to San Francisco's 36-9 win at MetLife Stadium.

Reed suffered a left ankle injury with 1:13 left in the first when he attempted to drag his feet in the back of the end zone on a throw from quarterback Nick Mullens. Reed was unable to make the catch and immediately grabbed for his left leg as he tumbled to the ground.

After getting the ankle checked out, Reed was able to return but he appeared to tweak his knee later in the half and did not return. Reed's departure left Ross Dwelley and Charlie Woerner as the Niners' only healthy remaining tight ends.

Niners coach Kyle Shanahan said after the game that he wasn't yet sure of the extent of Reed's injury.

"He came back from the ankle so he was good enough to come back from the ankle and play," 49ers coach Kyle Shanahan said. "But quickly, he ended up getting the knee [injury]. I'm not sure exactly the extent of it. I feel pretty optimistic it's not going to be anything long term or anything like that but we'll find out tomorrow."

Moseley's injury happened on the first play of the second quarter as he and safety Jaquiski Tartt converged on Giants quarterback Daniel Jones after a 19-yard run. Tartt and Moseley collided with Moseley taking the worst of it. Dontae Johnson replaced Moseley, who will enter the concussion protocol before he can return.

In addition to Reed and Moseley, Shanahan said running back Jerick McKinnon had an upper rib injury and linebacker Mark Nzeocha injured his quadriceps, which left both on the sidelines at the end of the game.

Those ailments only added to San Francisco's lengthy list of injury issues. Defensive end Dee Ford (back), quarterback Jimmy Garoppolo (ankle), linebacker Dre Greenlaw (quadriceps), tight end George Kittle (knee) and running back Raheem Mostert (knee) were all pregame inactives after suffering injuries last week against the Jets, a game also played at MetLife Stadium.

The Niners also are without running back Tevin Coleman (knee), receiver Richie James Jr. (hamstring), receiver Deebo Samuel (foot) and cornerback Richard Sherman (calf), all of whom are on injured reserve but expected to return in the coming weeks.

Defensive end Nick Bosa, defensive tackle Solomon Thomas and wideout Jalen Hurd are out for the season with torn anterior cruciate ligaments.