In a 31-17 victory Sunday, Jackson reached 5,000 yards passing and 2,000 yards rushing quicker than any player in NFL history. He recorded this feat in his 35th career game, which eclipsed Michael Vick (39 games).
Needing 96 yards passing to reach the 5,000-yard milestone, Jackson set the record on a 25-yard touchdown pass to Mark Andrews in the second quarter.
Jackson showed how dangerous he is running the ball earlier in the second quarter when he broke free for a 50-yard touchdown run, which is the longest of his career. It was the longest touchdown run by a quarterback in five seasons.
But Jackson didn't get all high-fives on that play. Jackson said he heard from coach John Harbaugh after he lifted the ball up in the air 15 yards away from the end zone and nearly got tackled before crossing the goal line.
"We watch 'plays of the week' [and] nine times out of 10 it's plays that you should not do, and I was almost on one of those plays," Jackson said. "That's basically what he was telling me on the sideline."
This marked the first time a player produced a touchdown run of 50 or more yards and a touchdown pass of at least 25 yards since Marcus Mariota in 2015.
"Lamar came up and just made some big touchdown throws; scramble plays, plays where he had great vision," Harbaugh said. "So, probably the key to the game right here."
Jackson's performance came after he produced a career-low 97 yards passing in a 34-20 loss to the Kansas City Chiefs on Monday night. He is now 22-1 against the rest of the league.
Jackson had an uneven passing performance on Sunday, completing 14-of-21 (66.7%) throws for 193 yards and two touchdowns and one interception. He ran for 52 yards on seven attempts.
"Lamar played great out there," Andrews said. "So when you have a guy like 'Eight' it's just fun to fly around and play games, and it was a good win."