It's not clear when Golladay was injured; he was not spotted on the sideline in the second half. Before his departure, Golladay was targeted four times by Matthew Stafford with no completions.
Coach Matt Patricia, when asked about Golladay's hip injury after the game, said the Lions had a couple of injuries they needed to sort through, but he had no other update.
Lions receiver Marvin Jones, who had two touchdowns in Detroit's loss, said he didn't see what happened to Golladay. In the second half without Golladay, the Lions had two touchdown drives but also had two drives end with a turnover.
"I don't know what happened, but it's always next man up," Jones said. "You see what Marvin Hall did out there. That's something that he does all day in practice and stuff like that. It's just next man up. That's what the NFL is about."
Hall, playing opposite Marvin Jones in Golladay's place, had four catches for 113 yards.
Despite missing two games earlier this season with a hamstring injury, Golladay has been Detroit's leading receiver with 20 catches for 338 yards and two touchdowns.
The Lions also targeted tight end T.J. Hockenson often during Sunday's game. In the first three quarters against the Colts, quarterback Matthew Stafford threw to Hockenson 10 times.
Lions returner/receiver Jamal Agnew also was ruled out with a rib injury. He suffered it on an 11-yard end-around in the second half.