He will undergo an MRI on Monday, according to coach Vic Fangio.
Jeudy suffered the injury on a third-and-7 play from the Giants' 33-yard line with just under nine minutes remaining in the third quarter. Broncos quarterback Teddy Bridgewater fired a pass to Jeudy along the left sideline for a 20-yard reception.
As Jeudy was tackled by Giants cornerback James Bradberry, his right leg became pinned as the players fell to the ground. Jeudy immediately grabbed his right ankle after the play as Broncos athletic trainers rushed onto the field.
Jeudy was quickly put on a cart as his teammates gathered around him and was taken to the locker room.
A source told ESPN's Jeremy Fowler that the initial X-ray on Jeudy's ankle was negative, confirming a report by NFL Network.
Jeudy, the Broncos' first-round pick in the 2020 draft, has been poised for a big season. He had six receptions for 72 yards on Sunday.