Coach Sean McVay said Friday that Henderson's availability would depend on pain tolerance after hurting his ribs on the first play of the fourth quarter in the Rams' 27-24 win at the Indianapolis Colts last weekend.
About an hour before kickoff, the Rams made it official, listing Henderson on their rundown of inactives, along with quarterback Bryce Perkins, safety JuJu Hughes, defensive back J.R. Reed, offensive lineman Alaric Jackson, tight end Brycen Hopkins and defensive lineman Bobby Brown III.
"We've got contingency plans in place. And if that's the case, then those other guys will be asked to step up," McVay said Friday.
Henderson didn't not practice this week. He has 123 yards rushing and two touchdowns on 29 carries through two games, along with four receptions for 46 yards.