Brown tweaked a hamstring in the first quarter and didn't return, playing only eight snaps before coming out.
Nick Westbrook-Ikhine took most of the snaps in Brown's place.
Brown had one carry for three yards. He didn't register a catch but was targeted twice before suffering the hamstring injury. For the season, Brown has seven receptions for 92 yards and a touchdown.
Titans rookie outside linebacker Rashad Weaver was carted off in the third quarter after going down with an apparent right leg injury.