Murray rolled his left ankle during individual drills on Saturday and was carted off. It's the same ankle Murray injured during the first quarter of the Chargers' 20-17 loss to the Dallas Cowboys on Sept. 19.
Cornerback Chris Harris Jr. is questionable and will be a game-time decision for Los Angeles (2-1). Harris has missed two games with shoulder issues and was limited in practice in all week. Defensive lineman Justin Jones will miss his third straight game with a calf injury. Jones practiced Thursday and Friday but sat out Saturday.