Chubb tested positive for COVID-19 last week, causing him to miss Cleveland's game in New England.
Browns coach Kevin Stefanski also confirmed that quarterback Baker Mayfield would start Sunday against the Lions. Mayfield has been dealing with left foot, right knee and left shoulder injuries, but Stefanski said the quarterback looked better and more mobile in practice Friday.
Chubb leads all NFL running backs with an average of 6.01 yards per carry. He is third overall in rushing with 721 yards to go along with six touchdowns.
The Browns also activated backup running back Demetric Felton off the reserve/COVID-19 list Friday. The rookie also tested positive for COVID-19 and sat out the New England game.
Cleveland's other standout running back, Kareem Hunt, remains on injured reserve with a calf injury. With Chubb and Hunt out, D'Ernest Johnson started against the Patriots and rushed for 99 yards as well as catching seven passes for 58 yards.