Swift exited the field and headed to the locker room during the second quarter after being pushed out of bounds by Bears linebacker Roquan Smith at Chicago's 32-yard line following a 2-yard gain.
"Yeah it's a wait-and-see. We know it's a shoulder sprain," Lions coach Dan Campbell said after the game. "We'll see where it goes."
Swift's day ended with three carries for zero rushing yards. He also had three receptions for 9 yards.
He leads the team with 555 rushing yards after posting back-to-back games of 130-plus rushing yards entering Thursday's holiday classic, which dates to 1934.