White is one of the team's best defensive players and was a significant loss for a unit that was almost back to full health. Backup Dane Jackson replaced him with Buffalo up 10-0.
When White is the nearest defender this season, the All-Pro corner is allowing a 50.8% completion percentage and 58.9 passer rating, both fourth-best among defensive backs with 50-plus targets this season, per NFL Next Gen Stats.
"Obviously Tre'Davious is a huge playmaker for us and just his presence on the football field is unmatched, and hopefully he's healthy," safety Micah Hyde said.
The injury occurred in the cornerback's home state. The Shreveport native attended LSU and was playing his first professional game in New Orleans.
In a quarter and a half against the Saints, White was targeted once, allowing zero receptions. The injury occurred while he was covering wide receiver Marquez Callaway. After walking off the field with a limp, he was visibly frustrated on the sideline before being examined in the team's medical tent and then heading to the locker room.
"I hope nothing's too serious, and I know all the guys in the locker room are praying for him and hurting with him," quarterback Josh Allen said. "You can't say a single bad thing about that man. He comes in and busts his ass every day."
Coach Sean McDermott did not have an update on White after the game, saying the team will take it one day at a time with the injury.