Shepard was writhing in pain as he toppled to the ground without contact while running a route with under two minutes left in the latest setback in the Giants' nightmare season. Fellow players immediately called for the medical staff, and Shepard was carted off.
"It's definitely tough," running back Saquon Barkley said of his close friend's injury. "He just sparks this team. He's a leader of this team. Just the energy he brings every single day, on the field, off the field. So anytime you see a guy go down, it's just a sad thing. But one thing I know about Shep, he's a fighter. It's a setback, but I know he's going to attack this rehab. ... Just a little setback, and the comeback is going to be something special."
The veteran receiver had two catches for 15 yards on that drive. He will finish the season with 36 receptions for 366 yards and a touchdown in seven games.
This continues the run of injuries to Shepard and the Giants' skill position players. Shepard already missed time because of injuries to both hamstrings, quad and calf. Barkley, wide receivers Kadarius Toney, Kenny Golladay and Darius Slayton, and tight end Evan Engram have each missed at least two games this season.
Shepard went into Sunday's game classified as questionable with a calf injury.
The latest setback could put his Giants future in jeopardy. Shepard, 28, is due almost $8.5 million next season.
However, outside linebacker Lorenzo Carter, who missed all of last season with a torn Achilles, voiced confidence in Shepard's ability to recover.
"It's a long process," Carter said. "I know my guy's got it in him. He's going to come back stronger than ever."