The Texans, along with supermarket chain H-E-B, are providing the Uvalde team with transportation to the stadium as well as suites for the game.
Members of the Texans visited Uvalde and spent time with the football team as it prepared for its home opener on Friday night, its first home game since the May 24 mass shooting as nearby Robb Elementary School.
Among the Texans contingent were CEO Cal McNair, vice president Hannah McNair, head coach Lovie Smith, linebackers Christian Kirksey and Kamu Grugier-Hill, along with director of sports medicine Roland Ramirez, who attended Robb Elementary.
The group spent the past two days with Uvalde and provided the football team with new Nike uniforms.
The Texans previously announced they will wear "Uvalde Strong" decals on their helmets against the Colts.
Nineteen children and two teachers were killed in the May 24 shooting, the deadliest school shooting in Texas history. In the days following the shooting, the Texans donated $400,000 to the Robb School Memorial Fund, while Texans players contributed $200,000.
In a dramatic home opener on Friday night, Uvalde scored the go-ahead touchdown on a one-handed catch with 12 seconds left before holding on for an improbable 34-28 victory.