Burks was unable to practice all week after leaving Sunday's game against the Indianapolis Colts late in the fourth quarter. The injury occurred when Burks caught a pass and tried to break a tackle as a Colts defender fell on his foot. Burks came out after the next play.
The 2022 first-round pick left the locker room on crutches with a boot on his foot. Burks finished the game with two receptions for 14 yards. Through four games, Burks has a total of 10 receptions for 129 yards and two rushing attempts for 8 yards.
The Titans will be without Burks for at least the next four games. Tennessee can designate Burks to return from practice after those four games, which would open up a 21-day window for him to be activated from injured reserve.
"Treylon is a tough guy to replace, but it gives the other guys an opportunity," quarterback Ryan Tannehill said. "Whoever ends up stepping in there for us and getting a bigger role is going to have to come huge for us."