Harris entered the day with a team-high 246 yards on 53 carries (4.6 average) with three touchdowns. The injury thrust Rhamondre Stevenson into the top role Sunday as the only other running back on the team's game-day roster.
The Patriots won the game 29-0.
Harris and Stevenson have split time through the first four games of the season, with Harris -- the fourth-year pro from the University of Alabama -- as the starter.
Stevenson entered the game with 211 rushing yards on 43 carries (4.9 average) and one touchdown. Stevenson also had 11 receptions for 57 yards entering the game.
In Sunday's game, Stevenson rushed for 161 yards on 25 carries -- a 6.4 average.
"... You've got to give him a ton of credit. With Damien out, we only carry two backs for the game. He put it all on his shoulders and finished with a couple first downs there at the end of the game in the four minute offense," Patriots coach Bill Belichick said.
If Harris' injury keeps him out beyond this week, the Patriots also have rookie running back Pierre Strong Jr. -- a fourth-round draft pick from South Dakota State -- on their 53-man roster. Strong was a healthy scratch for the Lions game.