Teller missed three games in 2020 with a similar calf injury. He suffered the injury during New England's 38-15 victory over the Browns this past Sunday. He's been wearing a boot around the Browns' practice facility this week.
Teller's injury is a blow to a Browns running game that leads the NFL with 1,032 yards. Hjalte Froholdt is expected to start in his place.
Cleveland will also be without star cornerback Denzel Ward (concussion) for a second consecutive game in Baltimore.
The Browns (2-4) have lost three games in a row.