Pierce, who had been listed as questionable, has appeared in seven games this season for Houston, rushing for 327 yards and a touchdown on 109 carries. He is second on the team in rushing, behind Devin Singletary (471).
The Texans have won three straight games and four of five. They will enter Sunday's contest one game behind the Jaguars for first place in the AFC South.
In Week 3, Houston coach DeMeco Ryans and rookie quarterback C.J. Stroud notched their first victories, when the Texans outlasted Jacksonville 37-17.
Houston has won five in a row against the Jaguars.