Kuper was blocking on a running play when rookie right tackle Orlando Franklin rolled into the back of his leg.
Before he was taken off the field on a cart, many of Kuper's offensive teammates came over to offer support, including quarterback Tim Tebow. Kuper is a stalwart on a young offensive line.
"Chris Kuper is a very good friend of mine and to see what happened to him really put a damper on things," said Chiefs quarterback Kyle Orton, a former Broncos teammate. "He's a great teammate, a great leader on that team and I hope he's able to get back as soon as possible."
Bowe appeared to be shaken up after a catch late in the first half. He walked off under his own power, but wasn't on the field for Kansas City's opening series of the second half.
Despite being shadowed by Pro Bowl cornerback Champ Bailey most of the game, Bowe had a big day. He had six catches for 93 yards.
"Dwayne was on fire in the first half, and then to lose him for the rest of the game, that really hurt our offense," Orton said. "I have the utmost respect for Champ Bailey, but Dwayne had him turning around in circles a couple times out there."
Information from The Associated Press contributed to this report.