Rob Lowe tweets about Peyton Manning

Rob Lowe is taking on another role -- pigskin prognosticator.

The actor lit up social media Wednesday when he tweeted that Peyton Manning was done.

Lowe said he'd heard from "my people" that the Indianapolis Colts quarterback would retire later in the day.

No official word yet from Manning, the 35-year-old star who missed this season with a neck injury.

ESPN senior NFL analyst Chris Mortensen spoke to Manning's father, Archie, on the phone and tweeted: "Archie Manning laughed when he heard @RobLowe said Peyton will retire, 'Noooo...he ain't retiring. I think he would've told me.' #NFL32."

Colts spokesman Avis Roper and Manning's agent ,Tom Condon, had no comment.

Lowe currently is on the NBC show "Parks and Recreation," which is set in Indiana. He's also friends with Colts owner Jim Irsay -- Lowe was the first person Irsay followed on Twitter.

Information from ESPN senior NFL analyst Chris Mortensen and The Associated Press was used in this report.