Schofield was injured in Sunday's 31-17 loss at Green Bay. Initially, it was thought it probably was only a sprain but further examination uncovered ligament damage that requires surgery.
Quentin Groves replaced Schofield in the game and is expected to do so when the team resumes play Nov. 21 at Atlanta. The Cardinals have a bye this week.
Schofield, a fourth-round draft pick out of Wisconsin in 2010, has 34 tackles and four sacks this season.