Kane collapsed after having his knee pinned to the boards in the right corner of the Devils' zone on a check from David Schlemko.
He was helped off the ice and did not return.
Coach Dan Bylsma did not have an update on Kane's status, but did say it was a "knee-on-knee" play.
"It's two guys battling, and they go in together, and he gets turned, and they're knee-on-knee that goes into the boards," Bylsma said. "I don't want to speculate."
A marquee acquisition for Sabres general manager Tim Murray last season, Kane missed all but 37 games for the Winnipeg Jets in 2014-15 after undergoing left shoulder surgery.
The Associated Press contributed to this report.