Letang had an assist in the loss.
Letang appeared to injure his left leg after colliding with Boston forward Joakim Nordstrom during the third period of Pittsburgh's 4-3 overtime victory Friday. He sat out a victory against the Los Angeles Kings on Saturday but appeared to be fine Monday.
The 31-year-old Letang had some initial concerns that this would be a longer-term injury. He says it's "better than what we expected" and he knew "right away what happened."
Letang now has seven goals and 19 assists in 31 games.
The Associated Press contributed to this report.