Merzlikins, 26, had been sidelined by an upper-body injury since he got hurt during practice on Feb. 3. He is 2-2-1 with a 2.76 goals-against average and a .913 save percentage in six games this season.
Columbus also recalled defenseman Andrew Peeke from its taxi squad ahead of Thursday night's game at Chicago.
Peeke, who turns 23 on March 17, was selected by the Blue Jackets in the second round of the 2016 draft. He made his NHL debut last season, finishing with a goal and two assists in 22 games.