The Devils said Hughes will not need surgery after an MRI confirmed no additional damage to his shoulder. The former No. 1 overall draft pick has begun physical therapy and will be evaluated again next week, when the team expects to determine a timetable for his return.
Hughes scored two goals in the Devils' season-opening win over the Chicago Blackhawks, including the game winner in overtime with a nifty backhand move.
Selected first overall by New Jersey in the 2019 draft, he had 11 goals and 20 assists in 56 games last season.
The Associated Press contributed to this report.