Barcelona's Messi has not featured for Argentina since captaining them at the World Cup, where they were knocked out by winners France.
Argentina take on Venezuela in Madrid on March 22 and the Czech Republic in Dresden, Germany, four days later, with the friendlies part of their preparations for the Copa America in June.
Argentina coach Lionel Scaloni said last week he had "a good feeling" the five-time Ballon d'Or winner would return in March.
Asked about Messi's possible return, Scaloni told reporters: "We will probably talk days before we provide the list for the FIFA March window.
"When the time comes, we will speak to him, and we have a good feeling. I hope he can be with us and be happy."
Scaloni, who took charge of Argentina on a temporary basis after the World Cup before accepting the role full-time last month, said his only regret so far was not having had the chance to coach Messi.
Messi, who spent Christmas in his native Rosario, has yet to publicly speak about his national-team future.